The brothers perform the banned alchemic technique of human transmutation in a effort to resurrect her when Trisha dies of the plague. As a result, the transmutation backfires and in law with equal exchange, the left leg and Alphonse's whole body of Edward are ruined. Edward loses his right arm to save Alphonse's soul, binding it having a blood seal into a suit of armour. Roy Mustang invites Edward to become a method to restore Alphonse's body to be researched by a State Alchemist. E
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